In this article, Timothy P. O'Toole and Ian Herbert discuss how U.S. regulators have been particularly active in the development of anti-money laundering (AML) regulations and priorities over the past year and analyze trends in U.S. AML regulation and enforcement to expect in the upcoming year. O'Toole and Herbert look at four key developments in U.S. money laundering regulation, including beneficial ownership registry, increased transparency in U.S. real estate transactions, focus on regulation of cryptocurrencies, and U.S. strategy on countering corruption. "Given the flurry of regulatory activity, combatting illicit finance is, and will continue to be, a top priority for the Biden administration," the authors wrote.